Occurrence of rpoB mutations in isoniazid-resistant but rifampin-susceptible Mycobacterium tuberculosis isolates from Germany.

نویسندگان

  • Sönke Andres
  • Doris Hillemann
  • Sabine Rüsch-Gerdes
  • Elvira Richter
چکیده

Four out of 143 phenotypically isoniazid-resistant but rifampin-susceptible Mycobacterium tuberculosis strains that were isolated from patients in Germany in 2011 had mutations in the rifampin resistance-determining region of rpoB. After performing drug susceptibility testing (DST) with two methods, the proportion method on Löwenstein-Jensen medium and using the Bactec 960 Mycobacteria Growth Indicator Tube system, we conclude that the two methods are equally reliable for phenotypic DST and MIC determination.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 58 1  شماره 

صفحات  -

تاریخ انتشار 2014